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Transplant-associated thrombotic microangiopathy and immune haematological complications following intestine-containing organ transplantation: experience from over 100 consecutive cases
Descriptions of passenger lymphocyte syndrome (PLS), immune cytopenias and transplant-associated thrombotic microangiopathy (TA-TMA) after intestine-containing transplants remain scarce.
Charlotte S Rutter 1, Neil K Russell 2, Lisa M Sharkey 1, Irum Amin 2, Andrew J Butler 3 Affiliations expand PMID: 33565629 DOI: 10.1111/ctr.14249 Abstract Introduction: This study reports the incidence of chronic kidney disease (CKD) after intestinal transplant (IT) at a single, adult center in the United Kingdom. Methods: A retrospective review of IT was undertaken. Methods of renal function assessment pre-transplant were compared. Post-transplant renal function…
Bortezomib for treatment-refractory autoimmune haemolytic anaemia following multivisceral transplantation
Darren Wong 1 2, William Thomas 3, Andrew Butler 4, Lisa Sharkey 5 Affiliations expand PMID: 33980556 PMCID: PMC8118027 (available on 2023-05-12) DOI: 10.1136/bcr-2021-241634 Abstract A 25-year-old man who received alemtuzumab as induction therapy for a multivisceral transplant experienced delayed onset of warm autoimmune haemolytic anaemia and neutropaenia. Serological testing and bone marrow biopsy excluded alternative causes. Haemolysis was refractory to standard therapies including corticosteroids, intravenous immunoglobulin and rituximab.…
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